Bee venom has special pharmacological activity for its enzymes and peptides containment. Melittin is the bee venom’s main constituent. The present work aimed in-vitro estimation of the anti-cancer potentials of bee venom (BV) in addition to evaluation of the synergetic potential of dates extract to bee venom against lung cancer (A549). BV showed a higher toxicity to A549 cells accompanied with synergetic activity of its toxicity in combination with dates extracts where the IC50 was arranged in the order of BV> Mix> Dates compared with doxorubicin as a positive control. Data revealed that BV/dates extract has a synergetic potential to BV that was accompanied with anticancer activity via up/down regulation of pro and anti apoptotic genes compared with control; caspase-3, Bcl-2 and pro-apoptotic gene (p53). Cell cycle analysis revealed that bee venom, dates and their mix induced pre G1 apoptosis and cell cycle arrest at G2/M phase.
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